The Cybermouse WWW Simulation Server
Sieburg, Hans B.)1)*, Donald E. Mosier)2, Jay M. Otero)1)**, and
Hubert Halkin )3.
)1 Laboratory for Biological Informatics and Theoretical Medicine,
Department of Psychiatry, 0603-H, University of California, San Diego, CA
92093-0603. )2 Department of
Immunology, Scripps Research Institute, La Jolla, CA 92037.
)3 Department of Mathematics, 0112, University of California, San
Diego, La Jolla CA 92093-0112, USA; )* Author to whom all
correspondence should be addressed; hsieburg@ucsd.edu ;)** Presenting
author.
- This talk describes the
Cybermouse (Mus
cyberspacea) simulation server at
Laborator
y
for Biological Informatics & Theoretical Medicine. The simulation
kernel of this MOSAIC server was designed using the
programming language SLANG of the CDM-DS simulator development system.
We described the CDM-DS previously
as an environment for the design of platform-independent complex adaptive
systems simulators.
- In collaboration with a variety of laboratories, we are
presently employing Cybermouse to augment the planning of distributed
wetlab
experiments in mouse model based AIDS research. Since AIDS is a complex
disease
that affects all of the major control systems of the body, any effort to
create
a vaccine or drug treatment involves a large number of specialist
interactions
between groups working on particular components of a project. The server
thus
solves two important problem in this area, namely how to provide rapid
communication of results, and how to prototype new experiments between
groups.
-
Present work focuses on expanding the Cybermouse concept to create an
environment for the planning of distributed clinical trials.
- This work is supported by grants from the National Institute of Mental
Health
(MH45688) and the National Science Foundation (CDA9404655) to H. Sieburg,
from
the National Institute for Allergies and Infectious Diseases (AI29182,
AI30238,
AI31686) to Donald Mosier, and the National Institute of Mental Health (MH18399) to Jay Otero.
--------------------------------------
appended biographies:
Dr. Hans B. Sieburg is an assistant adjunct professor in the Department of Psychiatry and a visiting assistant professor in the Department of Mathematics at the University of California, San Diego (UCSD). He is head of the Laboratory for Biological Informatics and Theoretical Medicine (BITMed) at UCSD. Dr. Sieburg studied mathematics at the University of Koln, Germany and received a Diploma (magna cum laude) in 1981 and Doctorate (magna cum laude) in 1983. He received the Minister for Education and Technology Travel Award, Japan (1983) and served as Fellow of the German Science Foundation (1984-85). He has received numerous research awards from the National Institute of Mental Health, Howard Hughes Medical Institute, and National Science Foundation. Dr. Sieburg has held positions at Stanford University, Princeton University, University of Texas, and the Salk Institute. He holds advisory positions for several scientific journals and serves as program coordinator/session chair for several scientific conferences on biological informatics and computers in medicine. Dr. Sieburg is married and resides in San Diego, California.
Donald E. Mosier, Ph.D., M.D. is a member in the Department of Immunology at the Scripps Research Institute. He is chief of the Division of Immunology at the Medical Biology Insititute in La Jolla, California and holds positions as adjunct professor in the Departments of Pathology at the University of California, San Diego and University of Pennsylvania School of Medicine. Dr. Mosier was born in 1944 in New York, New York. He received an A.B. in zoology at Indiana University in 1965 and a Ph.D. in pathology at the University of Chicago in 1969. Dr. Mosier attended the Pritzker School of Medicine, University of Chicago and received an M.D. with honors in 1971. His medical internship was served from 1971-72 in the Department of Pathology, Children's Hospital Medical Center, Boston. Dr. Mosier was a postdoctoral fellow, research associate, and senior investigator at the National Institutes of Health during 1971-1978. He was a research physician at the Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia from 1979-1985. Dr. Mosier has held editorial positions for two immunology journals and is a consultant on several pharmaceutical and research review committees. He is married and lives in Del Mar, California.
Jay Michael Otero, M.D. is a second-year Fellow in Clinical Psychopharmacology and Psychobiology at the University of California, San Diego. He was born at Westwood, New Jersey in 1963 and received a B.S. in biology, magna cum laude, from Virginia Commonwealth University in 1984. He worked as an emergency medical technician in 1985 and developed a computerized inspection report generator for his familyÕs business, Virginia Home Inspections, Inc. After receiving his M.D. in 1989 from the Medical College of Virginia, Dr. Otero completed a four-year residency in general psychiatry at the University of California, San Francisco -- Fresno. Dr. OteroÕs senior residency project employed a backpropagation neural network simulator to predict the clinical dispositions of suicidal patients. He received awards for best psychiatry resident and best residency project. Dr. Otero plans a future combined clinical, academic, and research career. He is unmarried and currently resides in La Jolla, California.
Hubert Halkin, Ph.D. is Emeritus Professor of Mathematics at the University of Calfornia, San Diego. He studied engineering at the University of Liege, Belgium, physics at Cambridge University, England, and mathematics at Stanford University where he received a Ph.D. in 1963. He was on the staff at Bell Telephone Laboratories from 1963 to 1965. Dr. Halkin has been on the faculty at UCSD since 1965 and was Chair of the Mathematics Department from 1981 to 1987. He was a visiting Professor of Economics at the University of Louvain, Belgium, in 1971-72 (on a Guggenheim fellowship) and a member of the Mathematics Research Center of the University of Montreal in 1972-73. He has been member on the editorial boards of four mathematics journals. Hubert Halkin is married and lives in La Jolla.
Correspondence should be addressed to hsieburg@ucsd.edu.